Increased GATA-3 and T-bet expression in eosinophilic esophagitis versus gastroesophageal reflux disease

J Allergy Clin Immunol. 2018 May;141(5):1919-1921.e5. doi: 10.1016/j.jaci.2017.12.993. Epub 2018 Jan 31.

Abstract

Eosinophilic esophagitis is associated with increased GATA-3 and T-bet expression in comparison to GERD and inactive EoE; moreover, parallel trends are observed in PPI-REE. Immunohistochemical assessment of the GATA-3+ and T-bet+ cells may help distinguish patients with EoE/PPI-REE from GERD and aid in assessment of treatment response.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Child
  • Child, Preschool
  • Eosinophilic Esophagitis / drug therapy
  • Eosinophilic Esophagitis / metabolism*
  • Female
  • GATA3 Transcription Factor / metabolism*
  • Gastroesophageal Reflux / drug therapy
  • Gastroesophageal Reflux / metabolism*
  • Humans
  • Male
  • Proton Pump Inhibitors / therapeutic use
  • RNA, Messenger / metabolism
  • Retrospective Studies
  • Th2 Cells / drug effects
  • Th2 Cells / metabolism

Substances

  • GATA3 Transcription Factor
  • GATA3 protein, human
  • Proton Pump Inhibitors
  • RNA, Messenger