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Review
. 2018 Apr;196(2):129-138.
doi: 10.1007/s00408-018-0084-z. Epub 2018 Jan 27.

Recent Advances in Bronchopulmonary Dysplasia: Pathophysiology, Prevention, and Treatment

Jung S Hwang  1 , Virender K Rehan  2
Affiliations
Free PMC article
Review

Recent Advances in Bronchopulmonary Dysplasia: Pathophysiology, Prevention, and Treatment

Jung S Hwang et al. Lung. 2018 Apr.
Free PMC article

Abstract

Bronchopulmonary dysplasia (BPD) is potentially one of the most devastating conditions in premature infants with longstanding consequences involving multiple organ systems including adverse effects on pulmonary function and neurodevelopmental outcome. Here we review recent studies in the field to summarize the progress made in understanding in the pathophysiology, prognosis, prevention, and treatment of BPD in the last decade. The work reviewed includes the progress in understanding its pathobiology, genomic studies, ventilatory strategies, outcomes, and therapeutic interventions. We expect that this review will help guide clinicians to treat premature infants at risk for BPD better and lead researchers to initiate further studies in the field.

Keywords: Bronchopulmonary dysplasia; Chronic lung disease of prematurity; Lung injury; PPARγ.

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Conflict of interest statement

Conflict of interest: Dr. Jung Hwang and Dr. Virender Rehan declare that they have no conflict of interest.

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Figure 1
Figure 1
Bronchopulmonary Dysplasia: Pathogenesis
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