DNA methylation alterations in the genome of a toddler with cri-du-chat syndrome

Oxana Y Naumova; Sergey Y Rychkov; Tatyana V Kuznetzova; Veronika V Odintsova; Sergey A Kornilov; Elena L Grigorenko

doi:10.1002/ccr3.1274

DNA methylation alterations in the genome of a toddler with cri-du-chat syndrome

Clin Case Rep. 2017 Nov 20;6(1):14-17. doi: 10.1002/ccr3.1274. eCollection 2018 Jan.

Authors

Oxana Y Naumova^{1

2}, Sergey Y Rychkov², Tatyana V Kuznetzova³, Veronika V Odintsova⁴, Sergey A Kornilov^{1

4}, Elena L Grigorenko^{1

4}

Affiliations

¹ Texas Institute for Measurement, Evaluation, and Statistics University of Houston Houston Texas.
² Laboratory of Human Genetics Vavilov Institute of General Genetics RAS Moscow Russian Federation.
³ D.O. Ott's Research Institute of Obstetrics, Gynecology and Reproductology Saint Petersburg Russian Federation.
⁴ Department of Psychology Saint-Petersburg State University Saint Petersburg Russian Federation.

Abstract

This manuscript reports on genomewide epigenetic alterations in cri-du-chat syndrome related to a partial aneusomy of chromosome 5. A systematic analysis of these alterations will open up new possibilities for the prognostic evaluation of CDCS patients and the development of new therapeutic interventions for reducing the severity of the disease.

Keywords: DNA methylation; Illumina Infinium Human Methylation450; case study; cri‐du‐chat syndrome.

Publication types

Case Reports