The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus

Exp Clin Endocrinol Diabetes. 2020 Feb;128(2):77-81. doi: 10.1055/s-0044-100376. Epub 2018 Jan 29.


Aim: The purpose of this study was to examine thiol-disulfide balance in patients with type 2 diabetes mellitus.

Methods: This study included 32 subjects with known type 2 diabetes mellitus without complications, 30 patients with type 2 diabetes mellitus with complications, 28 newly diagnosed patients with type 2 diabetes mellitus, and 45 healthy individuals. Thiol-disulfide profile tests were quantified in all groups.

Results: Compared to the control group, patients in each of the diabetic groups had significantly lower native and total thiol levels, higher disulfide levels, and higher disulfide/native thiol and disulfide/total thiol ratios (p<0.05 for all). Disulfide levels were significantly lower in the newly diagnosed group than in other diabetic groups (p<0.05). There were significant associations between glycemic parameters and thiol-disulfide tests (p<0.05).

Conclusions: A disequilibrium between thiol-disulfide pairs occurs in patients with type 2 diabetes mellitus, and a gradual increase to disulfide levels may contribute to the disease's severity. Deteriorated thiol-disulfide homeostasis may be relevant to the pathophysiology of type 2 diabetes mellitus.

MeSH terms

  • Diabetes Complications / blood*
  • Diabetes Mellitus, Type 2 / blood*
  • Disease Progression*
  • Disulfides / blood*
  • Female
  • Homeostasis*
  • Humans
  • Male
  • Middle Aged
  • Oxidative Stress*
  • Sulfhydryl Compounds / blood*


  • Disulfides
  • Sulfhydryl Compounds