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. 2018 Jan 4;4(2):FSO272.
doi: 10.4155/fsoa-2017-0086. eCollection 2018 Feb.

Evaluation of the Free-Radical Scavenging and Antioxidant Activities of Chilauni, Schima wallichii Korth in vitro

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Free PMC article

Evaluation of the Free-Radical Scavenging and Antioxidant Activities of Chilauni, Schima wallichii Korth in vitro

K Lalhminghlui et al. Future Sci OA. .
Free PMC article

Abstract

Aim: Free radicals are an outcome of various metabolic activities and their excess production leads to many diseases. Therefore, it is necessary to neutralize excess free radicals.

Materials & methods: Free-radical scavenging activity of various extracts of Schima wallichii was evaluated using standard protocols.

Results: Chloroform, ethanol and aqueous extracts of S. wallichii scavenged DPPH, hydroxyl, superoxide, nitric oxide and ABTS free radicals and increased ferric-reducing antioxidant potential in a concentration-dependent manner. A total of 1000 μg/ml of all the extracts and ethanol extract showed highest total flavonoids and phenol contents, respectively.

Conclusion: The different extracts of S. wallichii scavenged different free radicals efficiently due to the presence of flavonoids and polyphenols and may be helpful in free radical-induced diseases.

Keywords: DPPH; Schima wallichii; antioxidant; flavonoid; hydroxyl.

Conflict of interest statement

Financial & competing interests disclosure The authors are thankful to the University Grants Commission and Department of Biotechnology, Government of India, New Delhi for providing financial assistance to carry out this study. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Figures

<b>Figure 1.</b>
Figure 1.. The free-radical scavenging activity of different stem extracts of Schima wallichii.
(A) DPPH, (B) hydroxyl, (C) superoxide and (D) ABTS radicals. Dark gray: chloroform extract; gray: ethanol extract; and light gray: aqueous extract. The data are expressed as mean ± standard error of the mean; n = 5.
<b>Figure 2.</b>
Figure 2.. The free-radical scavenging activity of different stem extracts of Schima wallichii.
(A) ABTS (CHCl3), (B) Nitric oxide, (C) Ferric-reducing antioxidant potential (FRAP) radicals. Dark gray: chloroform extract; gray: ethanol extract; and light gray: aqueous extract. Values are expressed as mean ± standard error of the mean; n = 5.
<b>Figure 3.</b>
Figure 3.. The total phenol and flavonoid contents of different extracts of Schima wallichii (100–1000 μg/ml).
The data are expressed as mean ± standard error of the mean; n = 5. (A) Total phenols and (B) flavonoids.

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