Evaluation of the Free-Radical Scavenging and Antioxidant Activities of Chilauni, Schima wallichii Korth in vitro

Future Sci OA. 2018 Jan 4;4(2):FSO272. doi: 10.4155/fsoa-2017-0086. eCollection 2018 Feb.


Aim: Free radicals are an outcome of various metabolic activities and their excess production leads to many diseases. Therefore, it is necessary to neutralize excess free radicals.

Materials & methods: Free-radical scavenging activity of various extracts of Schima wallichii was evaluated using standard protocols.

Results: Chloroform, ethanol and aqueous extracts of S. wallichii scavenged DPPH, hydroxyl, superoxide, nitric oxide and ABTS free radicals and increased ferric-reducing antioxidant potential in a concentration-dependent manner. A total of 1000 μg/ml of all the extracts and ethanol extract showed highest total flavonoids and phenol contents, respectively.

Conclusion: The different extracts of S. wallichii scavenged different free radicals efficiently due to the presence of flavonoids and polyphenols and may be helpful in free radical-induced diseases.

Keywords: DPPH; Schima wallichii; antioxidant; flavonoid; hydroxyl.