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Review
. 2017 Nov;96(47):e8860.
doi: 10.1097/MD.0000000000008860.

Multiple Primary Cancer in the Female Genital System: Two Rare Case Reports and a Literature Review

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Free PMC article
Review

Multiple Primary Cancer in the Female Genital System: Two Rare Case Reports and a Literature Review

Wei Chai et al. Medicine (Baltimore). .
Free PMC article

Abstract

Rationale: Multiple primary cancer (MPC) refers to tumors that occur in one or multiple organs within the same patient at the same time or at different periods. MPC often occurs in the head and neck, but is rarely reported in the female genital system.

Patient concerns: In the present study, we report 2 rare cases that presented with tangible lower abdominal tumors.

Diagnoses: Laboratory tests, pelvic ultrasound (US), computed tomography (CT), and fast histopathological examinations during surgery indicated a diagnosis of MPC.

Interventions: The 2 patients all received radical resections of multiple tumors.

Outcomes: Postsurgical histopathological and immunohistochemical examinations further confirmed primary endometrial cancer and right ovarian cancer in Case 1, and primary cervical cancer and left ovarian cancer of Case 2. The 2 patients all recovered well without obvious complications.

Lessons: Our study demonstrated that female genital MPC should be noted for patients with multiple genital tumors. In addition, accurately diagnosis and radical surgical treatment should be well performed.

Conflict of interest statement

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Ultrasound (US) examination of uterine and right uterine adnexa of case 1. (A) US showing a thickened endometrium with uneven echoes and blood signals (black arrow). (B) US showing a 9.2 × 7.4 cm mass with uneven echoes in the right uterine adnexa (black arrow).
Figure 2
Figure 2
Pelvic enhanced computed tomography (CT) examination of case 1. Black arrow showing the thickened endometrium and white arrow showing a 5.8 × 7.4 cm tumor with uneven enhancement shadow in the right uterine adnexa.
Figure 3
Figure 3
Hematoxyilin and eosing (H&E) staining of the endometrial cancer (A) and right ovarian cancer (B) (magnification × 200).
Figure 4
Figure 4
Immunohistochemical staining of primary endometrial cancer (A) and right ovarian cancer (B) (magnification × 200).
Figure 5
Figure 5
Ultrasound (US) examinations of the cervix and right uterine adnexa of case 2. (A) US showing a swollen cervix with enhanced echoes and blood signals (white arrow). (B) US showing a 14.5 × 12.1 cm mass in the right uterine adnexa (white arrow).
Figure 6
Figure 6
Pelvic computed tomography (CT) examination of case 2. (A) A small mass with low density in the left cervical side wall (white arrow). (B) A large tumor mass with low density in the pelvic cavity (white arrow).
Figure 7
Figure 7
Hematoxyilin and eosing (H&E) staining of the cervical cancer (A) and right ovarian cancer (B) (magnification × 200).
Figure 8
Figure 8
Immunohistochemical staining of primary cervical cancer (A) and right ovarian cancer (B) (magnification × 200).

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