Role of proteoglycans in neuro-inflammation and central nervous system fibrosis

Matrix Biol. 2018 Aug:68-69:589-601. doi: 10.1016/j.matbio.2018.01.015. Epub 2018 Jan 31.

Abstract

Fibrosis is defined as the thickening and scarring of connective tissue, usually as a consequence of tissue damage. The central nervous system (CNS) is special in the sense that fibrogenic cells are restricted to vascular and meningeal areas. Inflammation and the disruption of the blood-brain barrier can lead to the infiltration of fibroblasts and trigger fibrotic response. While the initial function of the fibrotic tissue is to restore the blood-brain barrier and to limit the site of injury, it also demolishes the structure of extracellular matrix and impedes the healing process by producing inhibitory molecules and forming a physical and biochemical barrier that prevents axon regeneration. As a major constituent in the extracellular matrix, proteoglycans participate in the neuro-inflammation, modulating the fibrotic process. In this review, we will discuss the pathophysiology of fibrosis during acute injuries of the CNS, as well as during chronic neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and age-related neurodegeneration with focus on the functional roles of proteoglycans.

Keywords: Central nervous system; Fibrosis; Gliosis; Neuro-inflammation; Neurodegenerative diseases; Proteoglycans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood-Brain Barrier / metabolism
  • Central Nervous System / metabolism
  • Central Nervous System / pathology*
  • Fibrosis
  • Humans
  • Neurodegenerative Diseases / metabolism
  • Proteoglycans / metabolism*

Substances

  • Proteoglycans