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. 2018 Mar;371(3):531-539.
doi: 10.1007/s00441-017-2785-7. Epub 2018 Jan 30.

Neutrophils in Tissue Injury and Repair

Free PMC article

Neutrophils in Tissue Injury and Repair

Jing Wang. Cell Tissue Res. .
Free PMC article


As one of the first defenders of innate immune response, neutrophils make a rapid and robust response against infection or harmful agents. While traditionally regarded as suicidal killers that cause collateral tissue damage, recent findings on neutrophil extracellular trap formation, heterogeneity and plasticity and novel reparative functions have expanded our understanding of their diverse roles in health and disease. This review summarizes our current understanding of neutrophil-associated tissue injury, highlighting the emerging roles of neutrophil extracellular traps. This review will also focus on scrutinizing the roles of neutrophils in tissue repair and regeneration and will examine data on unexpected aspects of involvement of neutrophils in regulating normal tissue homeostasis.

Keywords: Angiogenesis; Injury; Neutrophils; Regeneration; Repair.


Fig. 1
Fig. 1
Neutrophil-mediated repair response. Three possible strategies that are adopted by neutrophils to promote tissue repair. I Neutrophils can clear necrotic cellular debris. A detailed mechanism in this progress remains to be studied. II Neutrophils release effectors that promote angiogenesis and regeneration; only “beneficial” effectors are listed in the figure. III Phagocytosis of apoptotic neutrophils results in release of anti-inflammatory and reparative cytokines

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