An unusual case of wheat dependent exercise induced anaphylaxis (WDEIA) triggered by Tri a 14 in a pediatric patient: a case report

Eur Ann Allergy Clin Immunol. 2018 Jul;50(4):187-189. doi: 10.23822/EurAnnACI.1764-1489.31. Epub 2017 Nov 23.


Anakinra, one of the novel biological agents, is a recombinant human IL-1 receptor antagonist. It is preferred as an alternative drug for familial Mediterranean fever cases where colchicine is not sufficient or cannot be used due to its side effects. Like all other biologics, hypersensitivity reactions to anakinra are quite rare. This is the first case which was successfully desensitized with anakinra after a severe immediate-type hypersensitivity reaction. We report a case of WDEIA in an asthmatic boy admitted to our Unit with suspected mushroom acute toxicity. The symptoms occurred during a gym session, approximately 2 hours after the ingestion of a meal based on pasta and cooked mushroom found in the family's garden. Acute toxicity due to mushroom ingestion was then excluded. Triptase serum levels resulted elevated in acute phase and normal after 24 hours. Food specific IgE showed a sensitization to lipid transfer protein Pru p 3 and to Tri a 14. This case highlights that WDEIA is underdiagnosed, especially when patients are firstly visited in Emergency Unit. Moreover, Tri a 14 is seldom described as responsible for WDEIA, compared to omega 5 gliadin.

Keywords: Ig-E mediated food allergy; food dependent exercise induced anaphylaxis; lipid transfer protein; wheat; wheat allergy.

Publication types

  • Case Reports

MeSH terms

  • Agaricales / immunology*
  • Anaphylaxis / immunology*
  • Antigens, Plant / immunology*
  • Asthma, Exercise-Induced / immunology
  • Carrier Proteins / immunology*
  • Child
  • Exercise*
  • Humans
  • Immunoglobulin E / blood
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Skin Tests
  • Triticum / immunology
  • Wheat Hypersensitivity / immunology*


  • Antigens, Plant
  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • Tri a 14 allergen, Triticum aestivum
  • Immunoglobulin E