Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa

Mar Drugs. 2018 Jan 31;16(2):47. doi: 10.3390/md16020047.

Abstract

Three new compounds, tuberazines A-C (1-3), and eleven known compounds (4-14) were obtained from the ethanolic extract of Taiwanese zoanthid Palythoa tuberculosa. Compounds 1-4 are rare marine natural products with a pyrazine moiety, and compound 5 is a tricyclic tryptamine derivative isolated from nature for the first time. The structures of all isolated metabolites were determined by analyzing their IR, Mass, NMR, and UV spectrometric data. The absolute configuration of 1 was confirmed by comparing the trend of experimental electronic circular dichroism (ECD) with calculated ECD spectra. The anti-lymphangiogenic activities of new compounds were evaluated in human lymphatic endothelial cells (LECs). Of these, new compound 3 displayed the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs.

Keywords: Palythoa tuberculosa; alkaloids; anti-lymphangiogenesis; pyrazines.

MeSH terms

  • Angiogenesis Inhibitors / pharmacology*
  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Endothelial Cells / drug effects
  • Humans
  • Lymphangiogenesis / drug effects*
  • Models, Molecular
  • Molecular Conformation
  • Taiwan
  • Tissue Extracts / pharmacology

Substances

  • Angiogenesis Inhibitors
  • Antineoplastic Agents
  • Tissue Extracts