Pre- And Post-Diagnosis Physical Activity, Television Viewing, and Mortality Among Hematologic Cancer Survivors

PLoS One. 2018 Jan 31;13(1):e0192078. doi: 10.1371/journal.pone.0192078. eCollection 2018.

Abstract

Purpose: The associations of physical activity and television (TV) viewing with mortality risk among individuals with hematologic malignancies remain unclear.

Methods: We examined the relations of physical activity and TV viewing time before and after diagnosis with mortality among 5182 U.S. adults aged 50-71 years from the NIH-AARP Diet and Health Study cohort who survived a first primary hematologic cancer between 1995-1996 and 2011.

Results: For the pre- and post-diagnosis analyses, we confirmed 2606 and 613 deaths respectively. In multivariable-adjusted Cox proportional hazard regression models, comparing high (≥4 hrs/wk) versus low (<1 hr/wk) activity levels, pre-diagnosis physical activity was associated with 18%-22% reduced risks of all-cause mortality among all hematologic cancer survivors, and survivors of non-Hodgkin lymphoma, myeloma, and leukemia, respectively. Additional control for BMI had little impact on the results, expect for myeloma survivors, for whom the association was no longer significant. Post-diagnosis physical activity was related to risk reductions in mortality ranging from 36%-47%. The associations for TV viewing did not show a clear pattern.

Conclusion: Our study suggests that pre- and post-diagnosis physical activity is associated with lower risk of all-cause mortality among hematologic cancer survivors. Further research is required to confirm this observation.

MeSH terms

  • Aged
  • Exercise*
  • Female
  • Hematologic Neoplasms / mortality
  • Hematologic Neoplasms / physiopathology*
  • Humans
  • Male
  • Middle Aged
  • Survivors*
  • Television*

Grant support

The author(s) received no specific funding for this work.