A minimally invasive catheter-based ultrasound technology for therapeutic interventions in brain: initial preclinical studies

Neurosurg Focus. 2018 Feb;44(2):E13. doi: 10.3171/2017.11.FOCUS17631.


OBJECTIVE Minimally invasive procedures may allow surgeons to avoid conventional open surgical procedures for certain neurological disorders. This paper describes the iterative process for development of a catheter-based ultrasound thermal therapy applicator. METHODS Using an ultrasound applicator with an array of longitudinally stacked and angularly sectored tubular transducers within a catheter, the authors conducted experimental studies in porcine liver, in vivo and ex vivo, in order to characterize the device performance and lesion patterns. In addition, they applied the technique in a rodent model of Parkinson's disease to investigate the feasibility of its application in brain. RESULTS Thermal lesions with multiple shapes and sizes were readily achieved in porcine liver. The feasibility of catheter-based focused ultrasound in the treatment of brain conditions was demonstrated in a rodent model of Parkinson's disease. CONCLUSIONS The authors show proof of principle of a catheter-based ultrasound system that can create lesions with concurrent thermode-based measurements.

Keywords: 6-OHDA = 6-hydroxydopamine; DBS = deep brain stimulation; HIFU; HIFU = high-intensity focused ultrasound; LAT = limb use asymmetry test; OFT = open field test; PD = Parkinson’s disease; Parkinson’s disease; RFA = radiofrequency ablation; STN = subthalamic nucleus; TTC = triphenyltetrazolium chloride; ablation; focused ultrasound; tcMRgFUS = transcranial MR-guided focused ultrasound.

MeSH terms

  • Animals
  • Brain / diagnostic imaging*
  • Brain / surgery
  • Catheterization / methods*
  • Minimally Invasive Surgical Procedures / methods*
  • Parkinsonian Disorders / diagnostic imaging*
  • Parkinsonian Disorders / surgery
  • Rats
  • Swine
  • Ultrasonography, Interventional / methods*