Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies

doi:10.1126/scitranslmed.aan5174

Review

. 2018 Jan 31;10(426):eaan5174.

doi: 10.1126/scitranslmed.aan5174.

Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies

Dario R Lemos^{1

2}, Jeremy S Duffield^{3

4}

Affiliations

¹ Renal Division, Brigham and Women's Hospital, Boston, MA 02115, USA. dlemos@bwh.harvard.edu jeremysd@u.washington.edu.
² Harvard Medical School, Boston, MA 02115, USA.
³ Department of Medicine, University of Washington, Seattle, WA 98195, USA. dlemos@bwh.harvard.edu jeremysd@u.washington.edu.
⁴ Research and Development, Vertex Pharmaceuticals, Boston, MA 02210, USA.

PMID: 29386358
DOI: 10.1126/scitranslmed.aan5174

Review

Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies

Dario R Lemos et al. Sci Transl Med. 2018.

. 2018 Jan 31;10(426):eaan5174.

doi: 10.1126/scitranslmed.aan5174.

Authors

Dario R Lemos^{1

2}, Jeremy S Duffield^{3

4}

Affiliations

¹ Renal Division, Brigham and Women's Hospital, Boston, MA 02115, USA. dlemos@bwh.harvard.edu jeremysd@u.washington.edu.
² Harvard Medical School, Boston, MA 02115, USA.
³ Department of Medicine, University of Washington, Seattle, WA 98195, USA. dlemos@bwh.harvard.edu jeremysd@u.washington.edu.
⁴ Research and Development, Vertex Pharmaceuticals, Boston, MA 02210, USA.

PMID: 29386358
DOI: 10.1126/scitranslmed.aan5174

Abstract

Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell (MSC) populations residing in different organs revealed unique properties and lineage capabilities that vary from one anatomical location to another. We review recently characterized tissue-resident MSC populations with a prominent role in fibrosis and highlight therapeutically relevant molecular pathways regulating their activity in chronic disease.

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Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies

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Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies

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