Measurement of meperidine and normeperidine in human breast milk by selected ion monitoring

Biomed Environ Mass Spectrom. 1986 Mar;13(3):133-5. doi: 10.1002/bms.1200130307.


A technique is described for extraction and quantitation of meperidine and normeperidine from breast milk by gas chromatography/mass spectrometry. Both compounds were measured in breast milk from parturients who received the drug for postpartum pain relief. The technique is sensitive to 1 ng ml-1 and standard curves were linear at 1.5-2000 ng ml-1. Levels in breast milk samples were 36.2-314 ng ml-1 and 0-333 ng ml-1 for meperidine and normeperidine, respectively. Preliminary results suggest that postpartum pain medication with meperidine results in considerable levels of both meperidine and its active metabolite, normeperidine, in breast milk.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Female
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Meperidine / analogs & derivatives*
  • Meperidine / analysis*
  • Milk, Human / analysis*


  • Meperidine
  • normeperidine