Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro

Drug Des Devel Ther. 2018 Jan 9;12:85-88. doi: 10.2147/DDDT.S153095. eCollection 2018.

Authors

Christine Pierrot¹, Xiguang Zhang², Gigliola Zanghi², Aline Fréville¹, Angelita Rebollo², Jamal Khalife¹

Affiliations

¹ Center for Infection and Immunity of Lille, U1019 - UMR 8204, Institut Pasteur de Lille, Université de Lille, Lille Cedex.
² CIMI Paris, UPMC/Inserm U1135, Paris, France.

No abstract available

MeSH terms

Antiprotozoal Agents / chemistry
Antiprotozoal Agents / metabolism
Antiprotozoal Agents / pharmacology*
Binding Sites / drug effects
Dose-Response Relationship, Drug
Leucine / chemistry*
Parasitic Sensitivity Tests
Peptides / chemistry
Peptides / metabolism
Peptides / pharmacology*
Plasmodium falciparum / chemistry*
Plasmodium falciparum / drug effects*
Plasmodium falciparum / growth & development
Protein Phosphatase 1 / chemistry*
Protein Phosphatase 1 / metabolism*
Structure-Activity Relationship

Substances

Antiprotozoal Agents
Peptides
Protein Phosphatase 1
Leucine