Animal models of contraception: utility and limitations

Open Access J Contracept. 2015 Apr 17;6:27-35. doi: 10.2147/OAJC.S58754. eCollection 2015.


Appropriate animal modeling is vital for the successful development of novel contraceptive devices. Advances in reproductive biology have identified novel pathways for contraceptive intervention. Here we review species-specific anatomic and physiologic considerations impacting preclinical contraceptive testing, including efficacy testing, mechanistic studies, device design, and modeling off-target effects. Emphasis is placed on the use of nonhuman primate models in contraceptive device development.

Keywords: contraceptive devices; in vivo; nonhuman primate; preclinical.

Publication types

  • Review