Animal models of contraception: utility and limitations

Open Access J Contracept. 2015 Apr 17;6:27-35. doi: 10.2147/OAJC.S58754. eCollection 2015.

Abstract

Appropriate animal modeling is vital for the successful development of novel contraceptive devices. Advances in reproductive biology have identified novel pathways for contraceptive intervention. Here we review species-specific anatomic and physiologic considerations impacting preclinical contraceptive testing, including efficacy testing, mechanistic studies, device design, and modeling off-target effects. Emphasis is placed on the use of nonhuman primate models in contraceptive device development.

Keywords: contraceptive devices; in vivo; nonhuman primate; preclinical.

Publication types

  • Review