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. 2018 Jan 13;5(1):e000668.
doi: 10.1136/openhrt-2017-000668. eCollection 2018.

Subclinical Magnesium Deficiency: A Principal Driver of Cardiovascular Disease and a Public Health Crisis

Free PMC article

Subclinical Magnesium Deficiency: A Principal Driver of Cardiovascular Disease and a Public Health Crisis

James J DiNicolantonio et al. Open Heart. .
Free PMC article

Erratum in


Because serum magnesium does not reflect intracellular magnesium, the latter making up more than 99% of total body magnesium, most cases of magnesium deficiency are undiagnosed. Furthermore, because of chronic diseases, medications, decreases in food crop magnesium contents, and the availability of refined and processed foods, the vast majority of people in modern societies are at risk for magnesium deficiency. Certain individuals will need to supplement with magnesium in order to prevent subclinical magnesium deficiency, especially if trying to obtain an optimal magnesium status to prevent chronic disease [corrected]. Subclinical magnesium deficiency increases the risk of numerous types of cardiovascular disease, costs nations around the world an incalculable amount of healthcare costs and suffering, and should be considered a public health crisis. That an easy, cost-effective strategy exists to prevent and treat subclinical magnesium deficiency should provide an urgent call to action.

Keywords: cardiovascular disease; deficiency; magnesium; mineral.

Conflict of interest statement

Competing interests: JJD is the author of The Salt Fix and operates the website the

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    1. Kielstein JT, David S. Magnesium: the ‘earth cure’ of AKI? Nephrol Dial Transplant 2013;28:785–7. 10.1093/ndt/gfs347 - DOI - PubMed
    1. Canelas HM, De Assis LM, De Jorge FB. Disorders of magnesium metabolism in epilepsy. J Neurol Neurosurg Psychiatry 1965;28:378–81. 10.1136/jnnp.28.4.378 - DOI - PMC - PubMed
    1. Wacker WE, Parisi AF. Magnesium metabolism. N Engl J Med 1968;278:658–63. 10.1056/NEJM196803212781205 - DOI - PubMed
    1. Martyka Z, Kotela I, Blady-Kotela A. [Clinical use of magnesium]. Przegl Lek 1996;53:155–8. - PubMed
    1. Vormann J. Magnesium: nutrition and metabolism. Mol Aspects Med 2003;24:27–37. 10.1016/S0098-2997(02)00089-4 - DOI - PubMed

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