The effect of vitamin D supplementation on thyroid autoantibody levels in the treatment of autoimmune thyroiditis: a systematic review and a meta-analysis

Endocrine. 2018 Mar;59(3):499-505. doi: 10.1007/s12020-018-1532-5. Epub 2018 Jan 31.


Purpose: Although observational studies suggested that vitamin D plays a role in autoimmune thyroiditis (AIT), intervention trials yielded inconsistent findings. We therefore conducted a systematic review and a meta-analysis to evaluate the effects of Vitamin D on decreasing autoantibodies in patients with AIT.

Method: We identified all studies that assessed the changes of TPO-Ab and Tg-Ab in patients with AIT under the treatment of vitamin D from PubMed, Embase, The Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and VIP Database.

Results: Six randomized controlled trials (RCTs) were included in this systematic review representing a total of 344 patients with AIT. The results showed that Vitamin D supplementation significantly dropped TPO-Ab titers [three studies, random effects standardized mean difference (SMD): -1.11, 95% CI -1.52 to -0.70, P < 0.01] at six months, but not at no more than 3 months [random effects SMD: -0.12, 95% CI: -0.69 to 0.44, P = 0.67]. As compared with control group, participants who received vitamin D supplementation demonstrated significantly lower Tg-Ab [random effects SMD: -0.55, 95% CI: -1.05 to -0.04, P = 0.033]. In addition, no serious adverse effect was reported.

Conclusions: The current evidence suggests that vitamin D supplementation could decrease serum TPO-Ab and Tg-Ab titers of patients with AIT in the short-term (about six months). More high quality studies are needed to further confirm the effects, especially the long-term effects of Vitamin D supplementation on thyroid autoantibodies levels in the treatment of AIT.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Autoantibodies / blood*
  • Dietary Supplements*
  • Humans
  • Iodide Peroxidase / immunology*
  • Thyroglobulin / immunology*
  • Thyroiditis, Autoimmune / blood
  • Thyroiditis, Autoimmune / drug therapy*
  • Thyroiditis, Autoimmune / immunology
  • Vitamin D / administration & dosage*
  • Vitamin D / therapeutic use


  • Autoantibodies
  • Vitamin D
  • Thyroglobulin
  • Iodide Peroxidase