Migraine and the risk of incident hypertension among women

Cephalalgia. 2018 Oct;38(12):1817-1824. doi: 10.1177/0333102418756865. Epub 2018 Feb 1.


Background Few studies have examined whether migraine is associated with an increased risk of incident hypertension. Methods We performed a prospective cohort study among 29,040 women without hypertension at baseline. Women were classified as having active migraine with aura, active migraine without aura, a past history of migraine, or no history of migraine. Incident hypertension was defined as new physician diagnosis or newly self-reported systolic or diastolic blood pressure ≥140 mmHg or ≥90 mmHg respectively. Cox proportional hazards models were used to evaluate the association between migraine and incident hypertension. Results During a mean follow-up of 12.2 years, 15,176 incident hypertension cases occurred. Compared to those with no history of migraine, women who experience migraine with aura had a 9% increase in their risk of developing hypertension (95% CI: 1.02, 1.18); women who experience migraine without aura had a 21% increase in their risk of developing hypertension (95% CI: 1.14, 1.28); and women with a past history of migraine had a 15% increase in their risk of developing hypertension (95% CI: 1.07, 1.23). Conclusions Women with migraine have a higher relative risk of developing hypertension compared to women without migraine.

Keywords: Migraine; epidemiology; hypertension; women.

MeSH terms

  • Cohort Studies
  • Female
  • Humans
  • Hypertension / complications
  • Hypertension / epidemiology*
  • Incidence
  • Middle Aged
  • Migraine Disorders / complications*
  • Prospective Studies
  • Risk Factors