Effectiveness, immunogenicity and safety of one vs. two-dose varicella vaccination:a meta-analysis

Expert Rev Vaccines. 2018 Apr;17(4):351-362. doi: 10.1080/14760584.2018.1433999. Epub 2018 Feb 6.


Background: Despite high 1-dose vaccination coverage, breakthrough varicella infections still occur. Therefore, 2-dose vaccination is recommended to enhance the immune response to the virus. However, the reported incremental vaccine effectiveness (VE) of 2-dose vaccination varies widely among studies.

Methods: To determine the overall effectiveness, immunogenicity and safety of one vs. two-dose varicella vaccination, we searched five databases for articles published during 1995-2017.

Results: The incremental VE/efficacy of 2-dose vaccination was 79% (95% confidence interval [CI]: 56%-90%) in randomized controlled trials,63% (95% CI: 36%-79%) in cohort studies and 81% (95% CI: 65%-90%) in case-control studies. Regarding immunogenicity, the pooled standardized mean differences (SMD) of geometric mean titer (GMT) and the pooled relative risk (RR) of seroconversion for 2-dose vs. 1-dose vaccine were 562.44 (95% CI: 471.78-653.10) and 1.03 (95% CI: 1.02-1.04), respectively. Children who received second dose vaccination were at increased risk of grade 3 redness (RR: 4.93, 95% CI: 1.89 - 12.87) and swelling of any intensity (RR: 1.34, 95% CI: 1.08 - 1.66).

Conclusions: Two-dose varicella vaccination resulted in higher levels of immunogenicity and provided superior protection than 1-dose vaccination. Safety profiles showed 2-dose vaccination was well tolerated but the incidence of grade 3 redness and of any intensity was significantly higher.

Keywords: 2-dose; Effectiveness; immunogenicity; safety; varicella vaccination.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chickenpox / prevention & control*
  • Chickenpox Vaccine / administration & dosage*
  • Chickenpox Vaccine / adverse effects
  • Chickenpox Vaccine / immunology
  • Child
  • Disease Outbreaks / prevention & control
  • Drug Administration Schedule
  • Humans
  • Randomized Controlled Trials as Topic
  • Vaccination / methods*


  • Chickenpox Vaccine