Abstract
Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Arabidopsis / drug effects*
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Arabidopsis / enzymology
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Ciprofloxacin / analogs & derivatives*
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Ciprofloxacin / chemistry
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Ciprofloxacin / pharmacology*
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DNA Gyrase / metabolism*
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Escherichia coli / drug effects*
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Herbicides / chemical synthesis
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Herbicides / chemistry
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Herbicides / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Topoisomerase II Inhibitors / chemical synthesis
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Topoisomerase II Inhibitors / chemistry
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Topoisomerase II Inhibitors / pharmacology*
Substances
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Anti-Bacterial Agents
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Herbicides
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Topoisomerase II Inhibitors
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Ciprofloxacin
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DNA Gyrase