Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Chem Commun (Camb). 2018 Feb 15;54(15):1869-1872. doi: 10.1039/c7cc09518j.

Abstract

Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Arabidopsis / drug effects*
  • Arabidopsis / enzymology
  • Ciprofloxacin / analogs & derivatives*
  • Ciprofloxacin / chemistry
  • Ciprofloxacin / pharmacology*
  • DNA Gyrase / metabolism*
  • Escherichia coli / drug effects*
  • Herbicides / chemical synthesis
  • Herbicides / chemistry
  • Herbicides / pharmacology*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Topoisomerase II Inhibitors / chemical synthesis
  • Topoisomerase II Inhibitors / chemistry
  • Topoisomerase II Inhibitors / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Herbicides
  • Topoisomerase II Inhibitors
  • Ciprofloxacin
  • DNA Gyrase