Effects of Rosmarinus officinalis L. on memory performance, anxiety, depression, and sleep quality in university students: A randomized clinical trial

Complement Ther Clin Pract. 2018 Feb;30:24-28. doi: 10.1016/j.ctcp.2017.11.004. Epub 2017 Nov 13.


Objective: To evaluate the effects of oral rosemary on memory performance, anxiety, depression, and sleep quality in university students.

Methods: In this double-blinded randomized controlled trial, the 68 participating students randomly received 500 mg rosemary and placebo twice daily for one month. Prospective and retrospective memory performance, depression, anxiety and sleep quality of the students were measured using Prospective and Retrospective Memory Questionnaire, Hospital Anxiety and Depression Scale, and Pittsburgh Sleep Quality Inventory at baseline and after one month.

Results: The scores of all the scales and subscales except the sleep latency and sleep duration components of Pittsburgh Sleep Quality Inventory were significantly decreased in the rosemary group in comparison with the control group after one month.

Conclusions: Rosemary as a traditional herb could be used to boost prospective and retrospective memory, reduce anxiety and depression, and improve sleep quality in university students.

Keywords: Anxiety; Depression; Memory; Rosemary; Sleep quality.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anxiety / drug therapy*
  • Anxiety Disorders / drug therapy
  • Depression / drug therapy*
  • Depressive Disorder / drug therapy
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Memory / drug effects*
  • Phytotherapy
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Prospective Studies
  • Retrospective Studies
  • Rosmarinus*
  • Sleep / drug effects*
  • Sleep Wake Disorders / drug therapy*
  • Students*
  • Surveys and Questionnaires
  • Universities
  • Young Adult


  • Plant Extracts