Synchronous diffuse large B-cell lymphoma of the stomach and small cell lung carcinoma: A case report

Medicine (Baltimore). 2017 Dec;96(50):e8873. doi: 10.1097/MD.0000000000008873.

Abstract

Rationale: The synchronous occurrence of lung cancer in patients with gastric neoplasms is relatively uncommon, especially the cases of synchronous coexistence of small cell lung carcinoma and diffuse large B-cell lymphoma of the stomach.

Patient concerns: We encountered a case of synchronous primary small cell lung carcinoma and diffuse large B-cell lymphoma of the stomach. A 63-year-old patient with a 7.5 × 5.09 cm mass in the superior lobe of the right lung diagnosed with small cell lung cancer and synchronous diffuse large B-cell lymphoma of the stomach.

Diagnoses: The diseases were diagnosed by the pathological biopsy and immunohistochemical methods.

Interventions: As the patient received CHOP chemotherapy, pulmonary function deterioraed. Etoposide was added to the chemotherapy.

Outcomes: However, after the first treatment, chest computed tomography showed that the mass in the superior lobe of the right lung had increased to 8.5 × 5.2 cm.

Lessons: This report draws attention to the fact that the treatment of synchronous tumors is a challenge.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols
  • Biopsy
  • Carcinoma, Small Cell / diagnosis*
  • Carcinoma, Small Cell / drug therapy
  • Carcinoma, Small Cell / pathology
  • Cyclophosphamide
  • Doxorubicin
  • Female
  • Gastroscopy
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / pathology
  • Lymphoma, Large B-Cell, Diffuse / diagnosis*
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Middle Aged
  • Neoplasms, Multiple Primary / diagnosis*
  • Neoplasms, Multiple Primary / drug therapy
  • Neoplasms, Multiple Primary / pathology
  • Prednisone
  • Stomach Neoplasms / diagnosis*
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / pathology
  • Tomography, X-Ray Computed
  • Vincristine

Substances

  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • CHOP protocol