Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun;55(2):51-56.
doi: 10.5152/tao.2017.2389. Epub 2017 Jun 1.

TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis

Onur İsmi  1 , Cengiz Özcan  1 , Gürbüz Polat  2 , Seval Kul  3 , Kemal Görür  1 , Tuğçe Pütürgeli  1
Affiliations

TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis

Onur İsmi et al. Turk Arch Otorhinolaryngol. 2017 Jun.

Abstract

Objective: Nasal Polyp (NP) is a benign mass of the paranasal sinuses that protrudes into the nasal cavity. The exact underlying pathogenesis is not known. In this study we aimed to determine the genetic susceptibility of NP formation in relation to TNF-α-308 and IL-1β-511 promoter region gene polymorphisms.

Methods: A total of 71 patients with NP with asthma (n=21) or without asthma (n=50) were taken as the study group, and 91 healthy volunteers were taken as the control group. Blood was gathered into EDTA-containing tubes, and patient DNA was extracted. The polymorphisms of the IL-β and TNF-α cytokine genes were analyzed using real time polymerase chain reaction.

Results: The GG genotype in the TNF-α-308 region and the CC genotype in the IL-1β-511 region were found to be risk factors for NP formation (OR: 9.2, p=0.007 and OR: 33.3, p=0.001, respectively). Regarding allelic frequencies, the G allele at the TNF-α-308 promoter region was a risk factor for NP formation (OR: 6.06, p<0.001).

Conclusion: TNF-α GG genotype in the -308 promoter region and the IL-1β CC genotype in the -511 region are genetic risk factors for NP formation.

Keywords: IL-1β; Nasal polyp; TNF-α; cytokine; genetic; polymorphism.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Similar articles

See all similar articles

Cited by

References

    1. Ozcan C, Tamer L, Ates NA, Gorur K. The glutathione-s-transferase gene polymorphisms (Gstt1, Gstm1, and Gstp1) in patients with non-allergic nasal polyposis. Eur Arch Otorhinolaryngol. 2010;267:227–32. https://doi.org/10.1007/s00405-009-1066-9. - DOI - PubMed
    1. Figueiredo CR, Silva IDC, Weckx LLM. Inflammatory genes in nasal polyposis. Curr Opin Otolaryngol Head Neck Surg. 2008;16:18–21. https://doi.org/10.1097/MOO.0b013e3282f363f1. - DOI - PubMed
    1. Bolger WE, Joshi AS, Spear S, Nelson M, Govindaraj K. Gene expression analysis in sinonasal polyposis before and after corticosteroids: a preliminary investigation. Otolaryngol Head Neck Surg. 2007;137:27–33. https://doi.org/10.1016/j.otohns.2007.01.023. - DOI - PubMed
    1. Mfuna Endam L, Cormier C, Bossé Y, Filali-Mouhim A, Desrosiers M. Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: A replication study. Arch Otolaryngol Head Neck Surg. 2010;136:187–92. https://doi.org/10.1001/archoto.2009.219. - DOI - PubMed
    1. Ozcan C, Apa DD, Pata YS, Gorur K, Akbas Y. Expression of inducible nitric oxide synthase in antrochoanal polyps. Int J Pediatr Otorhinolaryngol. 2003;67:383–8. https://doi.org/10.1016/S0165-5876(02)00405-6. - DOI - PubMed

LinkOut - more resources