Shaping the Pluripotent Genome: Switches, Borders, and Loops

Cell Stem Cell. 2018 Feb 1;22(2):148-150. doi: 10.1016/j.stem.2018.01.005.


Three-dimensional genome organization is largely cell type specific and requires reorganization during cell fate transitions. A recent study in Nature Genetics (Stadhouders et al., 2018) offers important insights into the principles and drivers of such reorganization during reprogramming of somatic cells into pluripotent stem cells.

Publication types

  • Comment

MeSH terms

  • Cell Differentiation
  • Cellular Reprogramming*
  • Genome
  • Pluripotent Stem Cells
  • Transcription Factors*


  • Transcription Factors