Rise of a Cereal Killer: The Biology of Magnaporthe oryzae Biotrophic Growth

Trends Microbiol. 2018 Jul;26(7):582-597. doi: 10.1016/j.tim.2017.12.007. Epub 2018 Jan 24.


The rice blast fungus, Magnaporthe oryzae, causes one of the most destructive diseases of cultivated rice in the world. Infections caused by this recalcitrant pathogen lead to the annual destruction of approximately 10-30% of the rice harvested globally. The fungus undergoes extensive developmental changes to be able to break into plant cells, build elaborate infection structures, and proliferate inside host cells without causing visible disease symptoms. From a molecular standpoint, we are still in the infancy of understanding how M. oryzae manipulates the host during this complex multifaceted infection. Here, we describe recent advances in our understanding of the cell biology of M. oryzae biotrophic interaction and key molecular factors required for the disease establishment in rice cells.

Keywords: apoplastic effectors.; appressorium; cytoplasmic effectors; rice blast.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle
  • Edible Grain / metabolism
  • Edible Grain / microbiology*
  • Fungal Proteins
  • Gene Expression Regulation, Plant
  • Host-Pathogen Interactions / physiology
  • Hyphae / cytology
  • Hyphae / growth & development
  • Magnaporthe / genetics
  • Magnaporthe / growth & development*
  • Magnaporthe / pathogenicity*
  • Magnaporthe / physiology*
  • Oryza / genetics
  • Oryza / metabolism
  • Oryza / microbiology
  • Plant Diseases / microbiology*
  • Plant Leaves / microbiology


  • Fungal Proteins