Heavy Water Shedding Light on Antigen-Specific T Cell Responses

Trends Immunol. 2018 Mar;39(3):170-172. doi: 10.1016/j.it.2018.01.003. Epub 2018 Jan 24.


CD8 T cells are crucial for long-term immunity. Nevertheless, the in vivo differentiation of human naïve CD8 T cells into effector and memory populations remains ill-defined. A recent study assesses the in vivo turnover of human antigen-specific CD8 T cells and suggests that long-lived memory cells arise from effector cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Antigens
  • CD8-Positive T-Lymphocytes / cytology
  • Cell Differentiation / immunology
  • Deuterium Oxide*
  • Humans
  • Immunologic Memory*


  • Antigens
  • Deuterium Oxide