Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Mar;39(3):170-172.
doi: 10.1016/ Epub 2018 Jan 24.

Heavy Water Shedding Light on Antigen-Specific T Cell Responses


Heavy Water Shedding Light on Antigen-Specific T Cell Responses

Liv Eidsmo et al. Trends Immunol. .


CD8 T cells are crucial for long-term immunity. Nevertheless, the in vivo differentiation of human naïve CD8 T cells into effector and memory populations remains ill-defined. A recent study assesses the in vivo turnover of human antigen-specific CD8 T cells and suggests that long-lived memory cells arise from effector cells.

Comment on

  • Origin and differentiation of human memory CD8 T cells after vaccination.
    Akondy RS, Fitch M, Edupuganti S, Yang S, Kissick HT, Li KW, Youngblood BA, Abdelsamed HA, McGuire DJ, Cohen KW, Alexe G, Nagar S, McCausland MM, Gupta S, Tata P, Haining WN, McElrath MJ, Zhang D, Hu B, Greenleaf WJ, Goronzy JJ, Mulligan MJ, Hellerstein M, Ahmed R. Akondy RS, et al. Nature. 2017 Dec 21;552(7685):362-367. doi: 10.1038/nature24633. Epub 2017 Dec 13. Nature. 2017. PMID: 29236685 Free PMC article.

Similar articles

See all similar articles

Publication types

LinkOut - more resources