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Comment
. 2018 Mar;39(3):170-172.
doi: 10.1016/j.it.2018.01.003. Epub 2018 Jan 24.

Heavy Water Shedding Light on Antigen-Specific T Cell Responses

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Heavy Water Shedding Light on Antigen-Specific T Cell Responses

Liv Eidsmo et al. Trends Immunol. .

Abstract

CD8 T cells are crucial for long-term immunity. Nevertheless, the in vivo differentiation of human naïve CD8 T cells into effector and memory populations remains ill-defined. A recent study assesses the in vivo turnover of human antigen-specific CD8 T cells and suggests that long-lived memory cells arise from effector cells.

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  • Origin and differentiation of human memory CD8 T cells after vaccination.
    Akondy RS, Fitch M, Edupuganti S, Yang S, Kissick HT, Li KW, Youngblood BA, Abdelsamed HA, McGuire DJ, Cohen KW, Alexe G, Nagar S, McCausland MM, Gupta S, Tata P, Haining WN, McElrath MJ, Zhang D, Hu B, Greenleaf WJ, Goronzy JJ, Mulligan MJ, Hellerstein M, Ahmed R. Akondy RS, et al. Nature. 2017 Dec 21;552(7685):362-367. doi: 10.1038/nature24633. Epub 2017 Dec 13. Nature. 2017. PMID: 29236685 Free PMC article.

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