Pseudomembranous colitis caused by topical clindamycin phosphate

Arch Dermatol. 1986 May;122(5):583-4.


Pseudomembranous colitis was observed on two occasions in the same patient and was associated with the topical administration of clindamycin phosphate. Assay for Clostridium difficile toxin was positive, and the patient was ultimately cured by oral vancomycin hydrochloride and the withdrawal of clindamycin therapy.

Publication types

  • Case Reports

MeSH terms

  • Acne Vulgaris / drug therapy
  • Administration, Topical
  • Adult
  • Bacterial Toxins
  • Clindamycin / adverse effects
  • Clindamycin / analogs & derivatives*
  • Clostridium
  • Enterocolitis, Pseudomembranous / etiology*
  • Enterocolitis, Pseudomembranous / microbiology
  • Female
  • Humans


  • Bacterial Toxins
  • Clindamycin
  • clindamycin phosphate