Association study of essential tremor genetic loci in Parkinson's disease

Neurobiol Aging. 2018 Jun;66:178.e13-178.e15. doi: 10.1016/j.neurobiolaging.2018.01.001. Epub 2018 Jan 6.

Abstract

A recent genome-wide association study identified variants associated with essential tremor (ET). The present study aimed to examine potential genetic overlap between ET and Parkinson's disease (PD). The top 22 variants identified by the ET genome-wide association study and 4 additional variants from previous studies were genotyped in a cohort of French and French-Canadian PD patients (n = 717) and controls (n = 595). Logistic regression analysis, adjusted for age and sex, was used to test for association between genotype and PD. None of the variants tested in the present study was significantly associated with PD. Our results do not support a role of ET-associated genetic variants in PD.

Keywords: Essential tremor; GWAS; Parkinson's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Canada
  • Cohort Studies
  • Essential Tremor / genetics*
  • Female
  • France
  • Genes, Overlapping / genetics*
  • Genetic Loci / genetics*
  • Genome-Wide Association Study*
  • Genomic Structural Variation / genetics*
  • Genotype
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Parkinson Disease / genetics*