Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System

ACS Chem Neurosci. 2018 Sep 19;9(9):2146-2161. doi: 10.1021/acschemneuro.7b00508. Epub 2018 Feb 19.

Abstract

The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term synaptic plasticity in brain regions involved in various neural functions ranging from action selection to appetite control. This review will explore the role of eCBs in shaping neural circuit function to regulate behaviors. In particular, we will discuss the behavioral consequences of eCB mediated long-term synaptic plasticity in different brain regions. This review brings together evidence from in vitro and ex vivo studies and points out the need for more in vivo studies.

Keywords: 2-arachidonoylglycerol; Arachidonoylethanolamine; cannabinoid receptors; depolarization-induced suppression of excitation; depolarization-induced suppression of inhibition; long-term depression; long-term potentiation.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Amygdala / metabolism
  • Amygdala / physiology
  • Animals
  • Arachidonic Acids / metabolism
  • Arachidonic Acids / physiology
  • Behavior, Addictive / metabolism
  • Behavior, Addictive / physiopathology
  • Brain / metabolism*
  • Brain / physiology
  • Cerebellum / metabolism
  • Cerebellum / physiology
  • Cerebral Cortex / metabolism
  • Cerebral Cortex / physiology
  • Conditioning, Psychological / physiology
  • Corpus Striatum / metabolism
  • Corpus Striatum / physiology
  • Endocannabinoids / metabolism*
  • Endocannabinoids / physiology
  • Extinction, Psychological / physiology
  • Fear
  • Glycerides / metabolism
  • Glycerides / physiology
  • Goals
  • Hippocampus / metabolism
  • Hippocampus / physiology
  • Humans
  • Neural Pathways
  • Neuronal Plasticity*
  • Polyunsaturated Alkamides / metabolism
  • Receptors, Cannabinoid / metabolism*
  • Receptors, Cannabinoid / physiology
  • Reward
  • Spatial Learning / physiology
  • Ventral Striatum / metabolism
  • Ventral Striatum / physiology

Substances

  • Arachidonic Acids
  • Endocannabinoids
  • Glycerides
  • Polyunsaturated Alkamides
  • Receptors, Cannabinoid
  • glyceryl 2-arachidonate
  • anandamide