A series of novel isoxazole-containing neonicotinoids were synthesized from nitromethylene analogues and aromatic aldehydes in the presence of l-proline/K2CO3. Bioassays indicated that several synthesized compounds showed 40-70% mortality against brown planthopper (Nilaparvata lugens) under the concentration of 4mgL-1, higher than that of imidacloprid (20%). Against cowpea aphid (Aphis craccivora), the best activity of title compounds reached 90% at the concentration of 20mgL-1.
Keywords: Imidacloprid; Insecticidal activity; Isoxazole; Neonicotinoids; Synthesis.
Copyright © 2017. Published by Elsevier Ltd.