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. 2018 Feb 15;28(4):831-833.
doi: 10.1016/j.bmcl.2017.06.046. Epub 2017 Jun 20.

Isoxazole-containing Neonicotinoids: Design, Synthesis, and Insecticidal Evaluation

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Isoxazole-containing Neonicotinoids: Design, Synthesis, and Insecticidal Evaluation

Chao Lei et al. Bioorg Med Chem Lett. .

Abstract

A series of novel isoxazole-containing neonicotinoids were synthesized from nitromethylene analogues and aromatic aldehydes in the presence of l-proline/K2CO3. Bioassays indicated that several synthesized compounds showed 40-70% mortality against brown planthopper (Nilaparvata lugens) under the concentration of 4mgL-1, higher than that of imidacloprid (20%). Against cowpea aphid (Aphis craccivora), the best activity of title compounds reached 90% at the concentration of 20mgL-1.

Keywords: Imidacloprid; Insecticidal activity; Isoxazole; Neonicotinoids; Synthesis.

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