Arene-Ligand-Free Ruthenium(II/III) Manifold for meta-C-H Alkylation: Remote Purine Diversification

Fernando Fumagalli; Svenja Warratz; Shou-Kun Zhang; Torben Rogge; Cuiju Zhu; A Claudia Stückl; Lutz Ackermann

doi:10.1002/chem.201800530

Arene-Ligand-Free Ruthenium(II/III) Manifold for meta-C-H Alkylation: Remote Purine Diversification

Chemistry. 2018 Mar 15;24(16):3984-3988. doi: 10.1002/chem.201800530. Epub 2018 Feb 21.

Authors

Fernando Fumagalli¹, Svenja Warratz¹, Shou-Kun Zhang¹, Torben Rogge¹, Cuiju Zhu¹, A Claudia Stückl², Lutz Ackermann¹

Affiliations

¹ Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstaße 2, 37077, Göttingen, Germany.
² Institut für Anorganische Chemie, Georg-August-Universität, Tammannstaße 4, 37077, Göttingen, Germany.

PMID: 29406613
DOI: 10.1002/chem.201800530

Abstract

meta-Selective C-H alkylations of bioactive purine derivatives were accomplished by versatile ruthenium catalysis. Thus, the arene-ligand-free complex [Ru(OAc)₂ (PPh₃ )₂ ] enabled remote C-H functionalizations with ample scope and excellent levels of chemo- and positional selectivities. Detailed experimental and computational mechanistic studies provided strong support for a facile C-H activation within a ruthenium(II/III) manifold.

Keywords: C−H activation; late-stage diversification; purines; remote functionalization; ruthenium.