Roles of Thyroid Transcription Factor 1 in Lung Cancer Biology

Vitam Horm. 2018;106:517-544. doi: 10.1016/bs.vh.2017.05.007. Epub 2017 Jun 20.


Thyroid transcription factor 1 (TTF-1 or NKX2-1) is a transcription factor of fundamental importance in driving lung maturation and morphogenesis. In the last decade, scientists began to appreciate the functional roles of TTF-1 in lung tumorigenesis. This movement was triggered by the discoveries of genetic alterations of TTF-1 in the form of gene amplification in lung cancer. Many downstream target genes of TTF-1 relevant to the lung cancer biology of TTF-1 have been documented. One of the most surprising findings was that TTF-1 may exhibit either pro- or antitumorigenic activities, an outcome with the complexity exceeding the original anticipation purely based on the fact that TTF-1 undergoes gene amplification in lung cancer. In the coming decade, we believe, we will witness additional surprises as the research exploring the cancer roles of TTF-1 progresses.

Keywords: 14q13.3; ABCA1; Lung cancer; Lung cancer secretome; Lung tumorigenesis; MUC5AC; Mucin; NKX2-1; SFTA3; TTF-1.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Biomarkers, Tumor
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation, Neoplastic / physiology*
  • Humans
  • Lung Neoplasms / classification
  • Lung Neoplasms / metabolism*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*


  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • TTF1 protein, human
  • Transcription Factors