An Intrinsic Interferon Program Protects Stem Cells from Viral Infection

Dev Cell. 2018 Feb 5;44(3):279-280. doi: 10.1016/j.devcel.2018.01.013. Epub 2018 Feb 5.


Specific protection mechanisms are required to safeguard stem cell integrity. In a recent issue of Cell, Wu et al. (2018) show that stem cells are equipped with high intrinsic expression of interferon-stimulated genes (ISGs) but remain refractory to acute interferon signaling. This protects stem cells from viral infection.

Publication types

  • Comment

MeSH terms

  • Humans
  • Interferons*
  • Stem Cells*


  • Interferons