When Telomerase Causes Telomere Loss

Dev Cell. 2018 Feb 5;44(3):281-283. doi: 10.1016/j.devcel.2018.01.011. Epub 2018 Feb 5.


Telomerase counteracts telomere shortening, preventing cellular senescence. Telomerase deficiency causes telomere syndromes because of premature telomere exhaustion in highly proliferative cells. Paradoxically, in a recent issue of Cell, Margalef et al. (2018) demonstrate that telomerase causes telomere loss in cells lacking the RTEL1 helicase, which is defective in Hoyeraal-Hreidarsson syndrome (HHS).

Publication types

  • Comment

MeSH terms

  • Cellular Senescence
  • Dyskeratosis Congenita
  • Humans
  • Microcephaly
  • Mutation
  • Telomerase / genetics*
  • Telomere Shortening
  • Telomere*


  • Telomerase