Vascular Permeability: Flow-Mediated, Non-canonical Notch Signalling Promotes Barrier Integrity

Andreas Fischer; Vania M M Braga

doi:10.1016/j.cub.2017.11.065

Vascular Permeability: Flow-Mediated, Non-canonical Notch Signalling Promotes Barrier Integrity

Curr Biol. 2018 Feb 5;28(3):R119-R121. doi: 10.1016/j.cub.2017.11.065.

Authors

Andreas Fischer¹, Vania M M Braga²

Affiliations

¹ Division Vascular Signaling and Cancer, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Medicine I, Heidelberg University Hospital, Im Neuenheimer Feld 671, 69120 Heidelberg, Germany.
² National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK. Electronic address: v.braga@imperial.ac.uk.

PMID: 29408259
DOI: 10.1016/j.cub.2017.11.065

Abstract

The vascular permeability barrier must be maintained in response to changes to vessel calibre, shear stress and blood pressure. A new study reveals a remarkable mechanism for flow-mediated regulation of permeability: Notch1 activation leads to the assembly of GTPase signalling complexes at VE-cadherin contacts and a strengthening of the endothelial barrier.

Vascular Permeability: Flow-Mediated, Non-canonical Notch Signalling Promotes Barrier Integrity

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