Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 83, 102-119

Wine and Its Metabolic Effects. A Comprehensive Review of Clinical Trials

Affiliations
Review

Wine and Its Metabolic Effects. A Comprehensive Review of Clinical Trials

Elizabeth Fragopoulou et al. Metabolism.

Abstract

The introduction of the term "French Paradox" motivated an extensive and in-depth research into health benefits of moderate wine consumption. The superiority of wine is thought to be attributed to its micro-constituents and consequent effort was made to isolate and identify these bioactive compounds as well as to elucidate the mechanisms of their action. Controlled trials offer more concrete answers to several raised questions than observational studies. Under this perspective, clinical trials have been implemented, mainly in healthy volunteers and rarely in patients, in order to investigate the acute or chronic effect of wine consumption on metabolism and physio-pathological systems, which are mainly associated with cardiovascular diseases. The aim of this review is to update the knowledge about the acute and long term effect of wine consumption on lipid and glucose/insulin metabolism as well as on the inflammatory and haemostatic systems, based on the reported data of controlled clinical trials. In conclusion, the most repeated result of wine consumption is on lipid metabolism, attributed mainly to ethanol, while wine micro-constituents seem to have an important role mainly in haemostatic and inflammatory/endothelial systems.

Keywords: Haemostasis; Inflammation; Long-term; PAF; Postprandial; Wine.

Similar articles

See all similar articles

Cited by 7 PubMed Central articles

See all "Cited by" articles

MeSH terms

Feedback