Lower Quadriceps Rate of Force Development Is Associated With Worsening Physical Function in Adults With or at Risk for Knee Osteoarthritis: 36-Month Follow-Up Data From the Osteoarthritis Initiative

Arch Phys Med Rehabil. 2018 Jul;99(7):1352-1359. doi: 10.1016/j.apmr.2017.12.027. Epub 2018 Jan 31.

Abstract

Objective: To determine the association between quadriceps rate of force development (RFD) and decline in self-reported physical function and objective measures of physical performance.

Design: Longitudinal cohort study.

Setting: Community-based sample from 4 urban areas.

Participants: Osteoarthritis Initiative participants with or at risk for knee osteoarthritis, who had no history of knee/hip replacement, knee injury, or rheumatoid arthritis (N=2630).

Interventions: Not applicable.

Main outcome measures: Quadriceps RFD (N/s) was measured during isometric strength testing. Worsening physical function was defined as the minimal clinically important difference for worsening self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function subscale score, 20-m walk time, and repeated chair stand time over 36 months.

Results: Compared with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an odds ratio (OR) of .68 (95% confidence interval [CI], .51-.92) after adjustment for age, sex, body mass index, depression, history of chronic diseases, and knee pain. In women, in comparison with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an adjusted OR of .57 (95% CI, .38-.86). This decreased risk did not reach statistical significance in men (OR, 0.81; 95% CI, 0.52-1.27). No statistically significant associations were detected between baseline RFD and walk or chair stand times.

Conclusions: Our results indicate that higher RFD is associated with decreased risk for worsening self-reported physical function but not with decreased risk for worsening of physical performance.

Trial registration: ClinicalTrials.gov NCT00080171.

Keywords: Knee; Muscle Strength; Osteoarthritis; Quadriceps muscle; Rehabilitation; Sports Medicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Female
  • Follow-Up Studies
  • Humans
  • Knee Joint*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Osteoarthritis, Knee / etiology
  • Osteoarthritis, Knee / physiopathology*
  • Physical Functional Performance*
  • Quadriceps Muscle / physiopathology*
  • Risk Factors
  • Time Factors
  • Torsion, Mechanical

Associated data

  • ClinicalTrials.gov/NCT00080171