Human cytomegalovirus infection and coronary heart disease: a systematic review

Virol J. 2018 Feb 6;15(1):31. doi: 10.1186/s12985-018-0937-3.


Background: Human cytomegalovirus (HCMV) infection is closely associated with coronary heart disease. In 1987, Adam et al. were the first to report an association between HCMV infection and atherosclerosis (AS), and later, many serum epidemiology and molecular biology studies showed that HCMV-infected endothelial cells play an important role in the development of AS. As patients with HCMV are generally susceptible to coronary heart disease, and with the increasing elderly population, a review of recent studies focusing on the relationships of HCMV infection and coronary heart disease is timely and necessary.

Short conclusion: The role of HCMV infection in the development of AS needs further study, since many remaining issues need to be explored and resolved. For example, whether HCMV promotes the development of coronary AS, and what the independent factors that lead to coronary artery AS by viral infection are. A comprehensive understanding of HCMV infection is needed in order to develop better strategies for preventing AS.

Keywords: Coronary heart disease; Human cytomegalovirus; Infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Animals
  • Atherosclerosis / epidemiology
  • Atherosclerosis / etiology
  • Atherosclerosis / metabolism
  • Blood Coagulation
  • Cell Movement
  • Cell Proliferation
  • Coronary Disease / epidemiology*
  • Coronary Disease / etiology*
  • Coronary Disease / metabolism
  • Cytomegalovirus Infections / complications*
  • Cytomegalovirus Infections / epidemiology
  • Cytomegalovirus Infections / virology
  • Cytomegalovirus* / physiology
  • Disease Models, Animal
  • Endothelial Cells / metabolism
  • Endothelial Cells / pathology
  • Endothelial Cells / virology
  • Humans
  • Immunomodulation
  • Inflammasomes
  • Lipid Metabolism
  • Population Surveillance


  • Inflammasomes