Transformation of Chlamydia: current approaches and impact on our understanding of chlamydial infection biology

Microbes Infect. 2018 Aug-Sep;20(7-8):445-450. doi: 10.1016/j.micinf.2018.01.002. Epub 2018 Feb 2.

Abstract

The intonation "The king is dead, long live the king" aptly describes the state of Chlamydia research. Genetic-based approaches are rapidly replacing correlative strategies to provide new insights. We describe how current transformation technologies are enhancing progress in understanding Chlamydia infection biology and present key opportunities for further development.

Keywords: Genetics; Mutagenesis; Pathogenesis; Transformation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Chlamydia / genetics
  • Chlamydia / pathogenicity
  • Chlamydia / physiology*
  • Chlamydia Infections / microbiology*
  • Chlamydia Infections / physiopathology
  • Cloning, Molecular
  • DNA Transformation Competence
  • Gene Transfer Techniques
  • Humans
  • Mutagenesis
  • Virulence Factors / genetics

Substances

  • Bacterial Proteins
  • Virulence Factors