Scalp Seborrheic Dermatitis and Dandruff Therapy Using a Herbal and Zinc Pyrithione-based Therapy of Shampoo and Scalp Lotion

Abstract

Objective: The aim of this study was to evaluate the safety and efficacy of an herbal and zinc pyrithione shampoo and a scalp lotion (Kamedis Derma-Scalp Dandruff Therapy, Kamedis Ltd., Tel Aviv, Israel) for the treatment of scalp seborrheic dermatitis and dandruff. Design: This was an interventional, open-label, safety and efficacy study. Setting: This open-label study was conducted at Consumer Product Testing Company Inc. in Fairfield, New Jersey. At the baseline visit (Day 0), an examination of the scalp was conducted by a board-certified dermatologist. The entire scalp was evaluated for evidence of seborrheic dermatitis using the Adherent Scalp Flaking Score with a 10-point scale. Only subjects with evidence of moderate-to-greater seborrheic dermatitis or moderate-to-greater dandruff were deemed qualified for inclusion in the study. Participants: Fifty subjects were recruited and included in the study. Measurements: Study subjects were evaluated by the same dermatologist for erythema and flaking at Days 0, 14, 28, and 42 using a five-point scale for each parameter. At each time point, a total severity score was calculated based on the findings of the evaluations. Following the scalp evaluation, each subject had a standardized digital photograph taken of his or her scalp. Each subject was also asked to answer a satisfaction questionnaire regarding the product treatment enhancement and characteristics. Results: A reduction in both parameters evaluated was seen at all time points. Statistical significance was achieved at each time point when compared with the baseline visit. In addition, the subjects expressed a high degree of satisfaction with the treatment. No adverse events were reported during this study. Conclusion: The study showed that the herbal zinc pyrithione shampoo and scalp lotion provided improvement in the main symptoms of seborrheic dermatitis.

Keywords: Kamedis; Seborrheic dermatitis; dandruff; erythema; loose flaking; lotion; scalp; shampoo; total severity score.

FIGURE 1.

Clinical appearance of patient with seborrheic dermatitis and dandruff: A) before and B) after six weeks of treatment with the dandruff care system

FIGURE 2.

Clinical appearance of patient with seborrheic dermatitis and dandruff: A) before and B) after six weeks of treatment with the dandruff care system

FIGURE 3.

Clinical appearance of patient with seborrheic dermatitis and dandruff: A) before and B) after 6 weeks of treatment with the dandruff care system

FIGURE 4.

A) Erythema index (mean) vs. duration (number of weeks) and B) erythema improvement (% compare to baseline) vs. duration (number of weeks from baseline)

FIGURE 4.

A) Erythema index (mean) vs. duration (number of weeks) and B) erythema improvement (% compare to baseline) vs. duration (number of weeks from baseline)

FIGURE 5.

A) Loose flaking index (mean) vs. duration (number of weeks); and B) Loose flaking improvement (percentage as compared with baseline) vs. duration (number of weeks from baseline)

FIGURE 5.

A) Loose flaking index (mean) vs. duration (number of weeks); and B) Loose flaking improvement (percentage as compared with baseline) vs. duration (number of weeks from baseline)

FIGURE 6.

A) Total severity score (mean) vs. duration (number of weeks); and B) total severity score improvement (% as compared with baseline) vs. duration (number of weeks from baseline)

FIGURE 6.

A) Total severity score (mean) vs. duration (number of weeks); and B) total severity score improvement (% as compared with baseline) vs. duration (number of weeks from baseline)

FIGURE 7.

Response of subjects when asked if they were satisfied with the product