The Positive and Negative Syndrome Scale (PANSS) is a well-established assessment tool for measuring symptom severity in schizophrenia. Researchers and clinicians have been interested in the development of a short version of the PANSS that could reduce the burden of its administration for patients and raters. The author presents a comprehensive overview of existing brief PANSS measures, including their strengths and limitations, and discusses some possible next steps. There are two available scales that offer a reduced number of original PANSS items: PANSS-14 and PANSS-19; and two shorter versions that include six items: Brief PANSS and PANSS-6. The PANSS-6 has been tested quite extensively in established trials and appears to demonstrate high sensitivity to change and an established cut off definition for remission. Prospective testing in new antipsychotic treatment trials is still required for these shorter versions of PANSS. In addition, they need to be supplemented with interview guides, as well as provide conversion formulas to translate total scores from the short PANSS versions to the PANSS-30. Both short versions of the PANSS are essentially designed to evaluate response to antipsychotic treatment. Future PANSS scale development needs to address specific measurement of treatment-responsive positive symptoms by including treatment-sensitive items, as well as illness-phase specific PANSS tools.
Keywords: Brief PANSS; PANSS; PANSS-6; Positive and Negative Syndrome Scale; patient assessment; schizophrenia.
Conflict of interest statement
FUNDING:No funding was provided for this article. DISCLOSURES:The author has no financial conflicts relevant to the content of this article.
PANSS-6: A Brief Rating Scale for the Measurement of Severity in SchizophreniaSD Østergaard et al. Acta Psychiatr Scand 133 (6), 436-44. PMID 26558537.PANSS-6 is a short schizophrenia severity rating scale that adequately separates antipsychotic efficacy from that of placebo.
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Understanding Antipsychotic Drug Treatment Effects: A Novel Method to Reduce Pseudospecificity of the Positive and Negative Syndrome Scale (PANSS) FactorsSC Hopkins et al. Innov Clin Neurosci 14 (11-12), 54-58. PMID 29410937. - ReviewThe Positive and Negative Syndrome Scale (PANSS) is the most widely used efficacy measure in acute treatment studies of schizophrenia. However, interpretation of the effi …
The Acute Efficacy of Antipsychotics in Schizophrenia: A Review of Recent Meta-AnalysesPM Haddad et al. Ther Adv Psychopharmacol 8 (11), 303-318. PMID 30344997. - ReviewSchizophrenia is the eighth leading cause of disability worldwide in people aged 15-44 years. Before antidopaminergic antipsychotics were introduced in the 1950s, no effe …
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