Randomized investigator-blinded comparative study of moisturizer containing 4-t-butylcyclohexanol and licochalcone A versus 0.02% triamcinolone acetonide cream in facial dermatitis

J Cosmet Dermatol. 2018 Dec;17(6):1130-1135. doi: 10.1111/jocd.12499. Epub 2018 Feb 6.


Background: Facial dermatitis can result from various conditions, some of which are of a chronic and relapsing nature. The use of topical corticosteroid therapy may lead to additional adverse effects.

Objective: To compare the efficacy of moisturizer containing 4-t-butylcyclohexanol, which acts as a sensitivity regulator, and licochalcone A, an anti-inflammatory agent from the licorice plant Glycyrrhiza inflata, with that of 0.02% triamcinolone acetonide (TA) for the treatment of facial dermatitis.

Methods: This was a randomized, prospective, investigator-blinded study. Eighty participants with mild to moderate facial dermatitis were randomly treated with either the test facial moisturizer or 0.02% TA twice daily for the first 2 weeks. For the subsequent 2 weeks, all patients used only the test moisturizer. Clinical assessment by investigators, bioengineering measurements, patients' subjective evaluation, and clinical photography were performed at baseline, week 2, and week 4.

Results: Both treatments showed a statistically significant improvement with regard to physician clinical assessment, skin hydration, transepidermal water loss, and patient-assessed visual analog scale after 2 and 4 weeks of treatment compared with baseline. The test facial moisturizer produced better skin hydration than TCS. The improvement in TEWL after 4 weeks of using the test moisturizer was comparable with 2-week treatment with 0.02% TA cream. However, subjective evaluation by patients indicated that TA more rapidly improved sensation sensitivity.

Conclusion: The test facial moisturizer was slower than 0.02% TA in improving facial dermatitis, but showed greater benefit in erythema control and skin hydration.

Keywords: 4-t-Butylcyclohexanol and Licochalcone A; facial dermatitis.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Inflammatory Agents / therapeutic use*
  • Chalcones / therapeutic use*
  • Cyclohexanols / therapeutic use*
  • Drug Therapy, Combination
  • Facial Dermatoses / drug therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Single-Blind Method
  • Skin Cream
  • Treatment Outcome
  • Triamcinolone Acetonide / therapeutic use*
  • Young Adult


  • Anti-Inflammatory Agents
  • Chalcones
  • Cyclohexanols
  • Triamcinolone Acetonide
  • licochalcone A
  • 4-tert-butylcyclohexanol