MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053

Nat Prod Res. 2019 Jan;33(1):66-73. doi: 10.1080/14786419.2018.1434636. Epub 2018 Feb 7.


A new medermycin derivative, MDN-0171 (1), and two known structurally related compounds, medermycin (2) and antibiotic G15-F (3) were isolated from the acetone extract of culture broths of the marine-derived Streptomyces albolongus strain CA-186053. Their structures were determined using a combination of spectroscopic techniques, including 1D and 2D NMR and electrospray-time of flight mass spectrometry (ESI-TOF MS). Compounds 2 and 3 accounted for the antimicrobial activity (against methicillin-resistant Staphylococcus aureus and Escherichia coli) previously detected in the crude extract of this actinomycete.

Keywords: Medermycin; marine natural products; pyranonaphthoquinone; structural elucidation.

MeSH terms

  • Actinobacteria
  • Anti-Bacterial Agents / isolation & purification
  • Escherichia coli / drug effects
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Naphthoquinones / chemistry
  • Spectrum Analysis
  • Streptomyces / chemistry*


  • Anti-Bacterial Agents
  • Naphthoquinones
  • medermycin