Pathology-Based Research in Africa

Maria P Lemos; Terrie E Taylor; Suzanne M McGoldrick; Malcolm E Molyneux; Manoj Menon; Steve Kussick; Nonhlanhla N Mkhize; Neil A Martinson; Andrea Stritmatter; Julie Randolph-Habecker

doi:10.1016/j.cll.2017.10.006

Pathology-Based Research in Africa

Clin Lab Med. 2018 Mar;38(1):67-90. doi: 10.1016/j.cll.2017.10.006.

Authors

Affiliations

¹ Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, E4-203, Seattle, WA 98101, USA.
² College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA; Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.
³ Seattle Genetics, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, 21823 30th Dr SE, Bothell, WA 98021, USA.
⁴ Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, UK.
⁵ Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, M1-B140, Seattle, WA 98109, USA; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, M1-B140, Seattle, WA 98109, USA; Department of Medicine, University of Washington, 1100 Fairview Avenue, M1-B140, Seattle, WA 98109, USA.
⁶ PhenoPath Laboratories, 551 North 34th Street #100, Seattle, WA 98103, USA.
⁷ Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), National Health Laboratory Service (NHLS), Johannesburg, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁸ Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Centre for HIV/AIDS and TB, University of the Witwatersrand, Johannesburg, South Africa; Johns Hopkins University, Center for Tuberculosis Research, Baltimore, MD, USA.
⁹ Pacific Northwest University of Health Sciences, 200 University Parkway, Room BHH 423, Yakima, WA 98901, USA.
¹⁰ Pacific Northwest University of Health Sciences, 200 University Parkway, Room BHH 423, Yakima, WA 98901, USA. Electronic address: j.habecker@focushisto.com.

Abstract

The process of conducting pathology research in Africa can be challenging. But the rewards in terms of knowledge gained, quality of collaborations, and impact on communities affected by infectious disease and cancer are great. This report reviews 3 different research efforts: fatal malaria in Malawi, mucosal immunity to HIV in South Africa, and cancer research in Uganda. What unifies them is the use of pathology-based approaches to answer vital questions, such as physiology, pathogenesis, predictors of clinical course, and diagnostic testing schemes.

Keywords: Burkitt lymphoma; Cancer; HIV/AIDS; Histopathology; Infectious disease; Malaria; Pathology.

Publication types

Review

MeSH terms

Africa
Biomedical Research*
Clinical Laboratory Services*
Developing Countries
Humans
Pathology, Clinical*

Abstract

Publication types

MeSH terms

Grants and funding