The timing, duration, and consolidation of sleep result from the interaction of the circadian timing system with a sleep-wake homeostatic process. When aligned and functioning optimally, this allows wakefulness throughout the day and a long consolidated sleep episode at night. Mismatch between the desired timing of sleep and the ability to fall and remain asleep is a hallmark of the circadian rhythm sleep-wake disorders. This article discusses changes in circadian regulation of sleep with aging; how age influences the prevalence, diagnosis, and treatment of circadian rhythm sleep-wake disorders; and how neurologic diseases in older patients affect circadian rhythms and sleep.
Keywords: Advanced sleep phase; Alzheimer disease; Circadian rhythm disruption; Circadian rhythm sleep disorders; Delayed sleep phase; Light therapy; Melatonin.
Copyright © 2017 Elsevier Inc. All rights reserved.