New Molecular Diagnostic Approaches to Bacterial Infections and Antibacterial Resistance

Annu Rev Med. 2018 Jan 29;69:379-394. doi: 10.1146/annurev-med-052716-030320.

Abstract

Recent advances in the field of infectious disease diagnostics have given rise to a number of host- and pathogen-centered diagnostic approaches. Most diagnostic approaches in contemporary infectious disease focus on pathogen detection and characterization. Host-focused diagnostics have recently emerged and are based on detecting the activation of biological pathways that are highly specific to the type of infecting pathogen (e.g., viral, bacterial, protozoan, fungal). Although this progress is encouraging, it is unlikely that any single diagnostic platform will fully address the clinician's need for actionable data with short turnaround times in all settings.

Keywords: gene expression profiling; host response diagnostics; host-pathogen interactions; infectious diseases diagnostics; nucleic acid biomarkers; point-of-care testing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bacterial Infections / diagnosis*
  • Bacterial Infections / drug therapy
  • Bacterial Infections / genetics
  • Bacterial Infections / metabolism
  • Biomarkers / metabolism
  • Drug Resistance, Bacterial / genetics*
  • Gene Expression Profiling
  • Humans
  • Molecular Diagnostic Techniques / methods*
  • Point-of-Care Testing

Substances

  • Biomarkers