[Ageing of hematopoietic stem cells]

Rinsho Ketsueki. 2018;59(1):3-12. doi: 10.11406/rinketsu.59.3.
[Article in Japanese]

Abstract

The frequency of clonal hematopoiesis in humans vastly increases with aging. Older adults may develop one or several clones and this condition is called clonal hematopoiesis of indeterminate potential (CHIP). Recent genetic analyses have identified the genes inducing CHIP. These mutant genes are detected frequently in elderly people and this condition is a precursor of hematopoietic neoplasms. The prevalence of hematopoietic neoplasms in patients with CHIP is tenfold that in those without CHIP. Consequently, the mechanism of aging and leukemogenesis of hematopoietic stem cells is being understood. Furthermore, the efficacy of senolysis, selectively removing scenescent cells from tissues, has been demonstrated in mice. The clinical application of senolysis is anticipated shortly.

Keywords: Ageing; CHIP; Hematopoietic malignancy; Hematopoietic stem cells.

Publication types

  • Review

MeSH terms

  • Aging
  • Animals
  • Cellular Senescence*
  • Clonal Evolution
  • Hematopoiesis
  • Hematopoietic Stem Cells*
  • Humans